PS:
The battery drain is not caused by the IP5306 itself, but by all the load is attached to (the 2V power the EA3036 on the main unit and the AMS1117 on the Lora)

Hi all...
Today i do a test to my M5Stack + Lora about weird working (with external usb, all is OK, with the internal battery, the Lora is not working or working badly).
I do not need much time to find the 2V on the 5V rail when M5 is in standby (where the lora take the power).
Search in the datasheet of the IP5306 and i found a 50uA for standby, but nothing for the Vout problem!!!
The only thing i see in the datasheet is the Auto Power On when Phone is inserted (the IP5306 is used for power banks)... i fear this is the problem.... I do a Test!!!
I attached a load to the 5V rail and, voilà, M5 is turning ON!!!
RESULT: The problem is the IP5306 itself!!!! Its a bad IC choice!!!