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Tadalista 60 mg is a high-strength formulation of Tadalafil, used to treat erectile dysfunction (ED) in men. Tadalafil belongs to the PDE5 inhibitor class of drugs, which work by increasing blood flow to the penis to help achieve and maintain an erection during sexual stimulation. Sexual arousal triggers the release of nitric oxide (NO) in the penile tissue. NO increases cyclic GMP (cGMP), which relaxes smooth muscles in the blood vessels, allowing blood to fill the penis. Tadalafil inhibits PDE5, the enzyme that breaks down cGMP, prolonging the erection.