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Malegra DXT Plus is a prescription combination medicine used to treat Erectile Dysfunction along with premature ejaculation in adult men. It contains two active ingredients: Sildenafil and Duloxetine. Sildenafil works by relaxing blood vessels and increasing blood flow to the penis during sexual stimulation, helping achieve and maintain a firm erection. Duloxetine works on the brain’s neurotransmitters (serotonin and norepinephrine), which can help reduce anxiety-related performance issues and may improve control over ejaculation.