@m5stack: I finally fixed "my" problem being not able to "see" the Atom Matrix on a mac with 10.15.x!!! At first I suspected a Wacom tablet driver which interferes with my serial port, but at the end it was an old FTDI driver helper named D2xxHelper. I figured out the problem by issuing this command
sudo ioreg -lirc IOUSBHostInterface
It gives detailed information on the USB connections and its drivers. For the "M5 Serial Converter" it stated the the D2xxHelper as driver (helper). By removing this old driver and rebuilding the kernel cache I was finally able to "see" my Atom Matrix on Catalina. Enclosed my commands:
sudo rm -rf /Library/Extensions/D2xxHelper.kext
sudo kextcache -i /
After this I've rebooted my mac.