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Modern infrastructure must have industrial control systems (ICS), which fuel sectors like manufacturing, energy, and transportation. Strong cybersecurity measures are now essential given the growing integration of operational technology (OT) and information technology (IT). The ISA-IEC-62443 standard, created by the International Society of Automation (ISA) and the International Electro Technical Commission (IEC), is one of the well-known frameworks in this field. In order to give readers a more comprehensive understanding of ISA-IEC-62443, we seek to address frequently asked questions and offer thoughtful responses in this article.