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Penegra 50 mg works by inhibiting the enzyme phosphodiesterase type 5 (PDE-5), which breaks down a substance called cGMP (cyclic guanosine monophosphate). cGMP is crucial for the relaxation of smooth muscles in the blood vessels of the penis, allowing for increased blood flow during sexual stimulation. By preventing the breakdown of cGMP, Penegra 50 mg helps maintain an erection.