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Malegra works by blocking the enzyme phosphodiesterase type 5 (PDE5). This increases levels of cGMP, which relaxes smooth muscles in blood vessels and allows more blood to flow into the penis during sexual arousal. It does not increase sexual desire and does not cause an erection without stimulation. Malegra usually begins working within 30–60 minutes after taking it. Its effects typically last around 4–6 hours, depending on dose, metabolism, food intake, alcohol use, and overall health. Heavy or fatty meals may delay its onset.